Life Sciences Division
1997-98
Progress Report

Contents

Foreword

Division

• Overview
• Mission
• Structure

Systems Biology

• Biochemistry & Biophysics
• Computational Biosciences
• Mammalian Genetics & Development

Technology Applications

• Assessment Technology
• Environmental Technology
• Toxicology & Risk Analysis

Infrastructure

• Lab Animal Resources
• Operations & Support
• Mouse Genetics Research
• DNA Sequencing Lab
• Gene Expression Chip Lab
• Dosimetry & Biokinetic
• Life Cycle Analysis
• Environmental Assessment

Partnerships

• Biological Sciences Institute
• Genome Science & Tech
• Tenn Mouse Genome Consortium

Initiatives

• Biological Sciences
• Functional Genomics & Proteomics
• Structural Biology
• Biomedical Engineering
• Technology Applications

Appendices

• Demographics
• Budget
• Division Pubs
• Open Literature Pubs
• ORNL & Misc. Reports
• Presentations
• U.S. Patents
• Invention Disclosures
• Honors, Awards, etc.
• Advisory Committee

LSD Home Page

Patents Issued, CY 1997-1998

Beattie, K. L.

U.S. Patent: 5,843,767
Date Issued: 12/1/1998
Flowthrough Porous Apparatus for Discrete Detection of Binding Reactions

Dees, H. C. (formerly of HSRD)

U.S. Patent: 5,698,429
Date Issued: 12/16/1997
Cellulase-containing cell-free fermentate produced from microorganism ATCC 55702

Dees, H. C. (formerly of HSRD)

U.S. Patent: 5,702,940
Date Issued: 12/30/1997
Cellulase producing microorganism ATCC 55702

Dees, H. C. (formerly of HSRD)

U.S. Patent: 5,756,337
Date Issued: 5/26/1998
Method of producing a cellulase-containing cell-free fermentate produced from microorganism ATCC 55702

Dees, H. C. (formerly of HSRD)

U.S. Patent: 5,780,422
Date Issued: 7/14/1998
Detergent composition comprising a cellulase containing cell-free fermentate produced from microorganism ATCC 55702 or mutant thereof

Dees, H. C. (formerly of HSRD)

U.S. Patent: 5,789,227
Date Issued: 8/4/1998
Processing of cellulosic material by a cellulase-containing cell-free fermentate produced from cellulase-producing bacteria, ATCC 55702

Easterly, C. E., A. A. Vass, R. L. Tyndall (retired)

U.S. Patent 5,597,729
Date Issued: 1/28/1997
Method for the removal and recovery of mercury

Foote, R. L. (now in CASD)

U.S. Patent: 5,661,028
Date Issued: 8/26/1997
Large scale DNA microsequencing device

Garrett, W. R. (retired)

U.S. Patent: 5,686,988
Date Issued: 11/11/1997
Gas concentration measurement instrument based on the effects of a wave-mixing interference on stimulated emissions

Knapp, F. F., Jr., A. L. Beets, S. Mirzadeh, and S. Guhlke

U.S. Patent: 5,729,821
Date Issued: 3/17/1998
Concentration of perrhenate and pertechnetate solutions

Mirzadeh, S., F. F. Knapp, Jr., and E. D. Collins

U.S. Patent: 5,774,782
Date Issued: 6/30/1998
Technetium-99m generator system

Thundat, T. G. and E. A. Wachter

U.S. Patent: 5,719,324
Date Issued: 2/17/1998
Microcantilever sensor

Tyndall, R. L. (retired)

U.S. Patent: 5,610,062
Date Issued: 3/11/1997
Dispersant solutions for dispersing hydrocarbons

Vo-Dinh, T.

U.S. Patent: 5,599,717
Date Issued: 2/4/1997
Advanced synchronous luminescence system

Vo-Dinh, T.

U.S. Patent: 5,721,102
Date Issued: 2/24/1998
Surface enhanced Raman gene probe and methods thereof

Vo-Dinh, T.

U.S. Patent: 5,783,389
Date Issued: 7/21/1998
Surface enhanced Raman gene probe and methods thereof

Vo-Dinh, T.

U.S. Patent: 5,814,516
Date Issued: 9/29/1998
Surface enhanced Raman gene probe and methods thereof

Vo-Dinh, T.

U.S. Patent: 5,864,397
Date Issued: 1/26/1999
Surface-enhanced raman medical probes and system for disease diagnosis and drug testing

Woychik, R. P. (formerly of Life Sciences Division)

U.S. Patent: 5,789,651
Date Issued: 8/4/1998
Isolation and characterization of Agouti: a diabetes/obesity related gene

Woychik, R. P. (formerly of Life Sciences Division)

U.S. Patent: 5,843,652
Date Issued: 12/1/1998
Isolation and characterization of Agouti: a diabetes/obesity related gene

Invention Disclosures, CY 1997-1998

Beattie, K. L.

ERID 0322, S-87,658
Microfabricated, Flowthrough Porous Apparatus for Discrete Detection of Binding Reactions
(submitted prior to LMER employment; Houston Advanced Research Center; assigned to LMER/DOE)
1997

Britton, C. L., Jr., R. J. Warmack, W. L. Bryan, R. L. Jones, P. I. Oden, and T. Thundat

ERID 0501, S-90,091
A Capacitively Readout Multielement Sensor Array with Common-Mode Cancellation
LDRD
5/98

Doktycz, M. J., W. L. Bryan, and R. Kress

ID 0644, S-90,891
Dual Manifold System for Arraying Biomolecules
LDRD-funded
11/98

Ferrell, T. L., M. L. Simpson, R. J. Warmack, P. B. Crilly, and D. L. Hedden

ERID 0337, S-87,689
Omnidirectional, Free-Space, Photonic, Multiconnect System for Electronic Circuits
KP01
4/97

Golovlev, V. V.

ID 0639, S-92,514
Fourier Transform Deconvolution for Enhancing Spectral Resolution
KP13
12/98

Kennel, S. J. and S. Mirzadeh

ERID 0266
Targeting of Alpha Particle Emitting Radioisotopes for Radiotherapy
KP14
8/98

Kuritz, T.

ERID 0463, S-90,042
Cultivation of a Bacterial Strain with an Accelerated Growth Rate
Division Overhead-funded
1/98

McPherson, D. W.

ERID 0531, S-90,822
In Vivo Method for Determination of Muscarinic Ligand Subtype Selectivity
KP14
6/98

Menon, M. M., T. G. Thundat, and P. I. Oden

ERID 0412, S-88-682
Miniature Vacuum Gauge and Residual Gas Analyzer Based on Microcantilever
Division Overhead-funded
9/97

Mirzadeh, S., S. Aaron, and L. Zevenbergen

ERID 0626, S-90,872
A New Indium-114m Brachytherapy Source
ST04
10/98

Oden, P. I., C. L. Britton, Jr., S. F. Smith, and R. J. Warmack

ID 0636, S-90,886
Multi-Modal Analysis of Micromechanical Structures for Sensing Applications
LDRD-funded
11/98

Pinnaduwage, L. A. and W. Ding

ID 0647, S-90,893
Method for Suppression of Dust Formation in Material Processing Discharges
EW40
11/98

Thundat, T. G., P. I. Oden, and P. G. Datskos

ERID 0357, S-88,601
Wavelength Dispersive Infrared Detector and Micro-Spectrometer Using Cantilevers
KP01
5/1/97

Thundat, T. G., I. Sauers, and P. I. Oden

ERID 0393, S-88,652
Microcantilever Detector for Gas Chromatography
KP01
7/18/97

Thundat, T. G. and P. I. Oden

ERID 0353,S-87,693
Acoustic Sensing Using Phased Array Microsensors
KP14
4/97

Thundat, T. G., P. I. Oden, and R. J. Warmack

ERID 0516, C-90,806
Micromechanical Transient Sensor for Measuring Viscosity and Specific Gravity
KP14
5/98

Thundat, T. G.

ERID 0545, S-90,840
Chemical Coatingless Chemical Sensors
KP14
7/98

Thundat, T. G. and T. L. Ferrell

ID 0651, S-90,900
Differential Phase Microcantilever Sensor
KP01
12/98

Varma, V. K., J. C. Lewis, D. A. Waters, T. G. Thundat, and C. M. Egert

ERID 0332, Y-87,672/ESID 1933-Y-87,672
Chemical Nano-Explosion Based Battery
RPSD Overhead
3/97

Vass, A. A. and R. L. Tyndall

ERID 0491, S-90,079
Antimicrobial Effect of an Amobae/Bacterial Preparation
ORNL Seed Money
4/98

Vo-Dinh, T. and A. Sadana

ERID 0349, S-88,606
Fractal Analysis with Space-Time (FAST) Coordinate Conversion
KP01
5/97

Vo-Dinh, T.

ERID 0309, S-88,681
SERMED Nanoprobes
KP01
9/97

Vo-Dinh, T., A. Wintenberg, and M. N. Ericson

ERID 0271, S-87,647
Integrated Circuit Microsystem (ICM) for DNA Biochips
KP01/LDRD
1997

Vo-Dinh, T. and S. J. Norton

ERID 0335, S-87,674
Spectro-Acoustically Enhanced Ultrasonic (SEUS) Detection for Biomedical Diagnosis
KP01
3/14/97

Vo-Dinh, T.

ERID 0454, S-90,030
Raman and Surface-Enhanced Raman Gene (SER-G) Probe and Detection System
KP01
1/98

Vo-Dinh, T.

ID 0659, S-90,908
SERS Biochip
KP11/LDRD
12/98

Vo-Dinh, T.

ID 0660, S-90,909
Advanced Multifunctional Biochip
KP11
12/98

Wachter, E. A., G. L. Powell, and J. E. Parks

ERID 0287C, S-87,686; ESID 1934-YC, S-87,686
Improved Method for Rapid Analysis of Synthetic Fibers
KJ02; CRADA ORNL 95-0352
4/97

Wachter, E. A., and C. M. Smith

ERID 0400, S-88,657
Microencapsulation Method for Munition Primers
Division overhead-funded
7/24/97

Woychik, R. P.

ERID 0402, S-88,662
Utilizing Yeast as an Intermediate Host for Constructing Mouse Gene Disruption Vectors by Homologous Recombination
WFO ERD-96-1374
8/97