Life Sciences Division
Oak Ridge National Laboratory

Invited review article featured on cover of Chemical Research in Toxicology (July 1998)

The May 1998, Volume 11, Number 5, issue of Chemical Research in Toxicology featured a graphic entitled "Arylamine-DNA Adducts" taken from an article co-authored by ORNL staff member, Brian E. Hingerty. The article is "Nuclear Magnetic Resonance Solution Structures of Covalent Aromatic Amine-DNA Adducts and Their Mutagenic Relevance," by Dinshaw J. Patel, Bing Mao, Zhengtian Gu, Brian E. Hingerty, Andry Gorin, Ashis K. Basu, and Suse Broyde. This invited review article featured a comprehensive review of all high resolution nuclear magnetic resonance solution structures of DNAs damaged by carcinogenic polycyclic aromatic amines, substances which are widespread in the environmental in tobacco smoke, automobile exhaust, and broiled foods. Much of the featured work represented seminal studies carried out in a collaboration involving the high resolution NMR laboratory of Dinshaw Patel at Memorial Sloan Kettering Cancer Center with Suse Broyde at New York University and Brian Hingerty at ORNL. The NERSC computer center at Lawrence Berkeley National Laboratory was the primary site for the computations in this extensive collaboratory. The studies have revealed the structural themes that these mutagenic substances adopt when attached to DNA, providing for the first time the molecular views which reveal the initiation event of carcinogenesis by these environmental chemicals–their attack on DNA which can lead to a mutation that may eventually produce tumors.

Funding Source: WFO

Contact: Brian Hingerty
Phone: 574-0844
E-mail: hingertybe@ornl.gov