Life Sciences Division
Oak Ridge National Laboratory

Research Highlights for 1998

December 1998
• Tennessee Mouse Consortium for Functional Genomics Memorandum of Cooperation Signed

November 1998
• Major Cryopreservation Effort for Mutant Mouse Stocks
• Genome Annotation Consortium Maps BAC Ends to Contigs of Human Genomic DNA Annotated in the Genome Channel
• Licensing Agreement with Graviton, Inc., for Research in Micromachined Sensors

October 1998
• Senior Staff Member Presents Invited Talk to CIRMS
• DOE Certifies M-100 Radwaste Boxes Made from Recycled Metal
• NCRP Publishes Report on Radionuclide Exposure to the Embryo/Fetus
• Center for Life Cycle Analysis Opens at ORNL
• ORNL Nuclear Medicine Programs Highlighted in DOE International Collaboration Effort

September 1998
• ORNL Nuclear Medicine Staff Organize and Participate in International Symposia
• Assessment Technology Staff Receives Contract to Evaluate Ink for the U.S. Postal Service
• Assessment Reports for National Program of Acute Exposure Guidance Levels
• Life Sciences Division Part of Initiative for Superconducting Transformer

August 1998
• Antibody-Based Nanosensor for Single-Cell Measurement
• ORNL/UT Collaborating Scientist Recipient of an Erskine Fellowship

July 1998
• Major publication completed in collaboration with U.S. Army
• Invited review article featured on cover of Chemical Research in Toxicology
• Dosimetry Research staff publish NCRP document on model uncertainties
• DOE/ORNL Workshop on Facility Disposition Principles
• Micromechanical infrared imager honored by Discover Magazine
• A new mutation that causes severe epilepsy in mice

June 1998
• Patent Disclosure Filed for Neural Activity Measurement Technique
• Genotyping of Short Insertion-Deletion Polymorphisms
• ORNL Protein Fold Prediction Program Succeeds in CASP3 Contest
• A novel gene in the mouse p region, expressed exclusively in the central nervous system, maps to a human chromosomal region associated with mental retardation

May 1998
• The Role of the Gene, fitness 1 (fit1), in iron metabolism and anemia
• Biosensing for Physiological Parameters
• Novel Analytical Techniques Based on an Enhanced Electron Attachment Process
• A Novel Energy-Efficient Plasma Chemical Process for the Destruction of Volatile Toxic Compounds
• Efficient Algorithms for Protein Threading and Folding
• Radon Mitigation Effort Completed on Guam
• National Center for Computational Modeling

February 1998
• Surface-Enhanced Raman Gene Probe for HIV Detection
• Tumor Blood Vessels Targeted with Radioisotopes in Cancer Therapy
• Cloning And Characterization of an Enzyme Integral To Photosynthetic Assimilation of Atmospheric Carbon Dioxide
• Laser Desorption Mass Spectrometry for Dynamic Mutation Analysis with Clinic Samples

January 1998
• Vascular-targeted alpha particle emitter destroys tumor colonies in lung
• A Mouse Model for the Human Angelman Syndrome
• Enhanced electron attachment to highly-excited molecules using a plasma mixing scheme
• Nuclear Medicine Group received DOE Laboratory Technology Research (LTR) funding for restenosis studies

Previous
• Research Highlights of 1997
• Research Highlights of 1996